Administration entails a high level of computerization and many other tasks with multiple risk factors (including psychosocial), affecting workers health and well-being. This study aims to determine the association between psychosocial factors and musculoskeletal discomfort among administrative staff. About 144 participants were involved in this study. Socio-demographic, musculoskeletal health and psychosocial data were collected from a composite questionnaire; Nordic Musculoskeletal Questionnaire (NMQ) and the Copenhagen Psychosocial Questionnaire (COPSOQ). The result showed that the highest prevalence of musculoskeletal discomfort for shoulders followed by neck and upper back for both male and female. The significant psychosocial factors were insecurity at work followed by influence at work. The highlighted result was a significant association between social support and job satisfaction with associated musculoskeletal pain region. In conclusion, proper organizational management and culture should be implemented to reduce the risk of psychosocial factor and musculoskeletal pain.