Cleaners are suffering from musculoskeletal disorders symptoms, which is contributed mainly by awkward postures, forceful exertion, and repetitive tasks. However, very few studies have been done on cleaners at college workplace. Thus, the objectives of the study are: (i) to evaluate working postures among the cleaners using REBA analysis; (ii) to evaluate discomfort level among cleaners using MSS body symptoms; (iii) to compare working postures among cleaners by task; (iv) to compare working postures among cleaners by workplace setting; and (v) to evaluate the relationship between REBA score and MSS body symptoms survey. Thirty IIUM cleaners between 27 to 63 years old of age [mean = 45.64; SD = 9.7] participated in this study. Four video clips were taken while the participants were doing four different tasks (one clip per task). From each video clip, three postures were selected and analyzed by using REBA analysis. In total, twelve postures were analyzed for each participant. In addition, participants were also asked to rate their discomfort level by using MSS body symptoms survey. The results showed that: (i) cleaners at college are exposed to a high risk for MSDs [REBA mean score = 7.86; SD = 0.861]; (ii) cleaners reported a high number of discomfort level [MSS mean score = 4.47; SD = 3.79]; (iii) the REBA score between the tasks are significantly different, F (3,356) = 26.282, p <0.001; (iv) the REBA score between the academic building and dormitory are not significantly different; and (v) there is no correlation between the REBA score (measured) and MSS score (self- reported). These findings show that cleaners at college workplace indeed expose to risk for musculoskeletal disorders, thus, awareness programs and proper training on ergonomics should be provided.