MSDs are major causes of work-related disability and lost time to illness. Mechanics usually perform manual material handling and are likely exposed to physical risk factors associated with MSDs. The objective of this study was to examine the relationship between Nordic Musculoskeletal Questionnaire (NMQ) and NIOSH lifting equation among mechanics at a tyre service centre.  This study was conducted in Taiping, Perak. A cross-sectional questionnaire survey was carried out among 239 workers from several workshop. Data were collected using a combination of structured questionnaire and interview session which are Nordic Musculoskeletal Questionnaire (NMQ) and Risk NIOSH Lifting tools. The NMQ was used to assess physical risks factors associated with the one of the body region within 12 months. In this research, 69.46%of mechanics have suffered musculoskeletal symptoms with the most troubled in the low back (64.4%), shoulder (54.0%) and elbow pain (46.8%). According to a NIOSH evaluation, most mechanics are at medium risk of developing musculoskeletal symptoms. There was a statistically significant relationship between physical risk and musculoskeletal disorders (p<0.05). Therefore, ergonomic awareness among mechanics should be increase in order to reduce the prevalence of musculoskeletal symptoms.